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NIHFOOD AND DRUG ADMINISTRATIONR01

Phase 2 Kp-10 in Patients with Hypogonadotropic Hypogonadism

Active
Institution
Massachusetts General Hospital, MA
Principal investigator
Stephanie Beth Seminara
Funding
$325K
Duration
2023–2028
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Abstract

PROJECT ABSTRACT Patients with idiopathic hypogonadotropic hypogonadism (IHH) have insufficient GnRH secretion. The lack of endogenous GnRH leads to absent LH and FSH, resulting in suppression of ovarian and testicular function and decreased levels of estradiol and testosterone. The neuropeptide kisspeptin is a powerful stimulus for GnRH induced LH secretion. The goal of this study is to explore the effects of pulsatile kisspeptin to stimulate the hypothalamic GnRH neurons of patients with HH. Thus, this application, if funded, can facilitate the translation of this therapeutic potential to the clinic.

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R01FOOD AND DRUG ADMINISTRATIONZFD1-OC-S(01)1testosteronesecretionstudy exploreexplore effectsfacilitate translationfshgnrhpulsatile

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