DC-HIL in cancer
INSTITUTION
VA NORTH TEXAS HEALTH CARE SYSTEM, TX
PRINCIPAL INVESTIGATOR
Cruz, Ponciano D (Contact)
FUNDING
—
YEAR
2018
MOONBASE SCORE
Still being scored
LOADING MOONBASE SCORE
Abstract
PROJECT SUMMARY Melanoma is a significant cause of morbidity and mortality in the U.S. and among military veterans. Having discovered an immune-vascular regulating pathway (DC- HIL/SD4) whose function can be manipulated to treat cancers, we will: (1) dissect its effects on immunity and vascularity in melanoma; (2) develop treatment targeted at a key carbohydrate component of the pathway; and (3) characterize changes in this component during melanoma growth and metastasis. Our results will improve current management of metastatic melanoma and potentially other cancers.
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