ANNOUNCEMENT

NOBEL PRIZE 2026

This year's laureates, their fields, and the discoveries that earned them the prize.Live nowSee the winners
Moonbase
← Back to Awards
NIHNATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASESR01

Microbiota, Probiotic and Dietary Metabolite Control of Enteric Pathogen Virulence

Active
Institution
SCRIPPS RESEARCH INSTITUTE, THE, CA
Principal investigator
Howard C Hang
Funding
$776K
Duration
2022–2027
Open portfolio

Moonbase score

Still being scored

Abstract

PROJECT SUMMARY Key metabolites from microbiota, probiotics and diet can inhibit the virulence properties of enteric pathogens, but their mechanisms of action are unclear and limit the development of new anti-infectives. To determine the mechanism(s) of action of prominent microbiota metabolites (short chain fatty acids, aromatic amino acids, bile acids and others), multi-disciplinary approaches are needed to biochemically identify metabolite-protein targets in enteric pathogens and characterize their activity on infections in vivo. My laboratory will therefore employ innovative methods in chemical biology, proteomics and gene editing in bacteria to elucidate how specific metabolites attenuates enteric pathogen infections. A better understanding of how these metabolites affects the virulence properties of bacterial pathogens should reveal potential therapeutic targets and facilitate the development of new anti-infectives to combat bacterial pathogens in animals and humans.

LOADING MOONBASE SCORE

R01NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASESSpecial Emphasis Panel[ZRG1-IDIA-Y(80)S]acidsmetabolitesvirulencepathogensmicrobiotabacterial pathogensenteric pathogensenteric

Questions for SCRIPPS RESEARCH INSTITUTE, THE

Answered by the team behind this research.

No questions yet. Sign in to ask the first one

Related grants

Same researchers, same institution, same topic, scored first.