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NOBEL PRIZE 2026

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NIHNATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKER01

Circadian regulation of neocortex

Active
Institution
Washington University, MO
Principal investigator
Erik Herzog
Funding
$325K
Duration
2021–2026
Open portfolio

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Abstract

Project Summary Little is known about the mechanisms that determine daily rhythms in rest-activity. We recently found that cells within the motor cortex can be synchronized to daily cycles of glucocorticoids. We hypothesize that daily suprachiasmatic nucleus activity and corticosterone secretion entrain circadian rhythms in cortical neurons and astrocytes to regulate daily patterns of behavior. We will take advantage of new high-throughput, machine learning and the ability to record and manipulate gene expression and calcium levels in specific cell types in mice. Combining these methods with two-color, real-time imaging of gene expression simultaneously in neurons and astrocytes, we will determine the roles of cortical neurons and glial in distinct daily activities.

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R01NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKEBehavioral Neuroendocrinology, Neuroimmunology, Rhythms, and Sleep Study Section [BNRS]neuronsdailycorticalcircadianrhythmsastrocytescortical neuronsneurons astrocytes

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