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NOBEL PRIZE 2026

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NIHNATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASESR01

Imaging signatures of early tuberculosis

Active
Institution
RUTGERS BIOMEDICAL AND HEALTH SCIENCES, NJ
Principal investigator
Yingda Linda Xie
Funding
$643K
Duration
2023–2028
Open portfolio

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Abstract

ABSTRACT Early detection of tuberculosis (TB) disease to prevent transmission and disability is hampered by the lack of precise biomarkers to diagnose and predict TB progression. The objective of this study is to develop computational imaging tools to characterize and diagnose individuals without TB symptoms who will progress to sputum culture-positive or symptomatic TB disease. In Aim 1, we will combine computed tomography (CT) scans from existing and prospective TB household contact studies to derive a high-resolution radiomic signature to predict and characterize early disease pathology. In Aim 2, we will evaluate methods to enhance performance of field-deployable chest-X-ray computer aided detection (CAD) systems to diagnose early TB using transfer learning, image-to-image training, and integration of clinical and epidemiologic variables. Our goal is to develop a fundamental toolbox for research, diagnosis, and targeted preventive treatment of early TB to prevent transmission and accelerate TB control.

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R01NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASESPopulation based Research in Infectious Disease Study Section[PRID]diagnosesputumtuberculosistransmissiondevelop fundamentalpathology aimenhance performanceradiomic

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