Quorum Sensing Regulation of EHEC Virulence Genes

See continuation page 24 for project summary. Per NIH instructions, submit a one-page abstract of the research plan for the entire extension period (3-5 years) RELEVANCE (See instructions): The goal of this project is to investigate how different host neurotransmitters impact the balance among microbiota-pathogen-host interactions. We will assess how the stress hormones epinephrine and norepinephrine have their impact on enterohemorrhagic E. coli (EHEC) virulence gene regulation counteracted by an endocannabi noi d. We will also investigate how the microbiota alters the availability of the active form of these neurotransmitters in the gut.