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NOBEL PRIZE 2026

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NIHNATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCESR35

Renewal: Strategies and Methods for Complex Molecule Synthesis

Active
Institution
UNIVERSITY OF CALIFORNIA BERKELEY, CA
Principal investigator
Richmond Sarpong
Funding
$664K
Duration
2019–2027
Open portfolio

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Abstract

Project Summary/Abstract The goal of this program is to develop new strategies and methods for the synthesis of biologically active secondary metabolites (natural products). A significant portion of our efforts will be dedicated to identifying efficient preparations of these complex molecules. These compounds and their unique derivatives will serve as novel small molecules to combat a range of indications associated with cancer as well as inflammation and pain. Our synthetic studies will lead to new applications of C–H, C–C and C–N bond functionalization methodology in organic synthesis as well as advancing the concept of skeletal editing and its application to the preparation of topologically complex molecules. Finally, working with collaborators, we will gain unique entry into the use of natural products and their derivatives to perturb biological function and ultimately provide promising starting points for new therapeutics.

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R35NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCESMaximizing Investigators’ Research Award B Study Section[MRAB]moleculessynthesisnatural productstopologicallynovel smallassociated cancerderivativesbiologically active

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