Realizing Accelerated Progress, Investigation, Implementation, and Dissemination in Learning Health Systems (RAPID-LHS) Center

Realizing Accelerated Progress, Investigation, Implementation, and Dissemination in Learning Health Systems (RAPID-LHS) Major gaps exist between the generation of clinical evidence, widespread implementation of proven interventions, and formulation of informed policy. The learning health system (LHS) aims “to generate and apply the best evidence for the collaborative healthcare choices of each patient and provider; to drive the process of discovery as a natural outgrowth of patient care; and to ensure innovation, quality, safety, and value in healthcare.” Vanderbilt will formally train a cadre of RAPID-LHS scientists well versed in the best methods for integrating patient-centered outcomes, evidence implementation, and evaluation of health policies within the LHS. We propose to establish the Realizing Accelerated Progress, Investigation, Implementation, and Dissemination in Learning Health Systems (RAPID-LHS) Center to train faculty to conduct high-impact research that is embedded in the LHS. In cross-training scientists and embedding them in the health system, we will draw together scientists and mentors across disciplines and model the team science integral to LHS. We will provide forums that demonstrate the intellectual productivity and practical benefits of interdisciplinary research in advancing human health. We endorse team approaches to filling gaps in knowledge and translating knowledge into application. A diverse pool of scientists from internal (Vanderbilt University Medical Center) and partner health systems (Meharry Medical College, the VA Quality Scholars Program, Vanderbilt University, Vanderbilt Health Affiliated Network, Safety Net Clinics, and the STAR Clinical Research network) is available. Career milestones for scientists will include impact on health equity, population health and patient health, publications and grants. LHS lessons learned during project development will advance LHS science. All RAPID-LHS scientists will conduct embedded projects in conjunction with Research and Data Analysis Core (RDAC), focusing on 1) patient-centered outcomes research, 2) dissemination and implementation science, 3) health policy/public health, 4) stakeholder engagement and health equity, and 5) methods advancement. Each embedded project will begin with in-depth feedback from a Community Engagement Studio and LHS Platform Studio, which will follow a structured process to ensure that the clinical question is important and that the research is needed. All scientists will then meet with RDAC mentors to determine their needs and prepare a structured workplan. The research will use a health equity lens to prevent unintended consequences of interventions in the health system. Each scientist will engage in integrated didactic and experiential training through the Research Education Core. The RAPID-LHS scientists’ progress will be facilitated by VUMC’s rich environment for training in LHS and supporting projects with real-world impact.