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NOBEL PRIZE 2026

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NIHNATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASESR01

Tissue-Anchored vs. Circulating Engineered Enzyme Constructs for Immunometabolic Resolution of Psoriasis

Active
Institution
University of Florida, FL
Principal investigator
Benjamin George Keselowsky
Funding
$741K
Duration
2023–2028
Open portfolio

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Abstract

Project Summary/Abstract We have developed innovative new approaches of administering immunotherapeutic enzymes that robustly directs immune cells away from chronic inflammation toward homeostasis through metabolic programming. Innovative fusion protein enzyme constructs in both tissue-anchored and circulating forms are investigated, quantifying cellular mechanisms of action in order to determine if different administration routes offer advantages. There is considerable need for new therapeutic options for the chronic auto-inflammatory disease, psoriasis, which irreversibly damage epidermal tissues.

Research team

  • Dorina AvramPI
  • Benjamin George KeselowskyPI

LOADING MOONBASE SCORE

R01NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASESGene and Drug Delivery Systems Study Section[GDD]enzymeimmunometabolicfusion proteinpsoriasisinnovative newcirculatingorder determineconstructs

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