ANNOUNCEMENT

NOBEL PRIZE 2026

This year's laureates, their fields, and the discoveries that earned them the prize.Live nowSee the winners
Moonbase
← Back to Awards
NIHNATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCESR35

Molecular and Cellular Dynamics in Mammalian Signal Transduction

Active
Institution
UNIVERSITY OF COLORADO, CO
Principal investigator
Natalie G. Ahn
Funding
$638K
Duration
2020–2030
Open portfolio

Moonbase score

Still being scored

Abstract

PROJECT SUMMARY This MIRA proposal addresses two important avenues of discovery made by our laboratory. In Project 1, we will examine a novel mechanism for allosteric regulation of the MAP kinase, ERK2. This project advances the protein kinase field, by investigating in-depth how protein motions underlie the activation of ERK and how this affects cellular responses to inhibitors of this important enzyme. In Project 2, we will investigate a well-known observation that has never been fully explained, that the responses of cells vary with the strength of ERK signaling. Project 2 advances the signaling field, by discovering and characterizing molecular and cellular events controlled at different thresholds of ERK activity.

LOADING MOONBASE SCORE

R35NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCESMaximizing Investigators' Research Award C Study Section[MRAC]allostericcellular responsescellular dynamicssignaling projectmolecular cellularkinaseerkproject advances

Questions for UNIVERSITY OF COLORADO

Answered by the team behind this research.

No questions yet. Sign in to ask the first one

Related grants

Same researchers, same institution, same topic, scored first.