Core B: Biostatistics and Computational Biology Core

CORE B- BIOSTATISTICS AND COMPUTATIONAL BIOLOGY CORE PROJECT SUMMARY The Dana-Farber/Harvard Cancer Center Specialized Program of Research Excellence in Breast Cancer (DF/HCC SPORE in Breast Cancer) Biostatistics and Computational Biology Core (Core B) collaborates with and provides consultation on all research activities within the SPORE, including SPORE Projects, Developmental Research and Career Enhancement Projects, and other SPORE Cores, to ensure the highest standards of scientific rigor in areas of study design, data management and integrity, and data analysis and interpretation. The overarching goal of the SPORE is to promote translational research derived from fundamental discoveries in the laboratory that can lead to tangible clinical benefit. To this end, the Biostatistics and Computational Biology Core will collaborate with other Cores to create an integrated system of resource support for the SPORE. The Breast Cancer Biostatistics and Computational Biology Core has a wealth of experienced biostatisticians equipped with excellent computational support, including major commercial and public-use statistical software, and a large library of locally written software for design and analysis. The Core will leverage the computational biology and bioinformatic expertise within the Projects and across DF/HCC resources and ensure conceptual, data management and analytic integration across the Projects and Cores. Organizing biostatistical expertise as a shared resource core, with effective integration of computational biology expertise, is a cost-effective approach to ensure that collaboration is readily available to SPORE investigators and to promote the highest standards of translational research.