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NIHNATIONAL HEART, LUNG, AND BLOOD INSTITUTE

Core C: Electrophysiology Core

Active
Institution
Beth Israel Deaconess Medical Center, MA
Principal investigator
Elda Arrigoni
Funding
$382K
Duration
2020–2030
Open portfolio

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Still being scored

Abstract

Project Summary/Abstract The Electrophysiology Core (Core C) will provide services for in vitro electrophysiological studies using novel tools such as optogenetics and in vitro GCaMP6 calcium imaging. We will prepare brain slices, conduct patch- clamp recordings, channelrhodopsin2 (ChR2)-assisted circuit mapping (CRACM), and Ca2+ imaging studies in brain slices. The Core will also perform histology of the recorded slices and analyze the associated data. Project 1 (Saper), Project 2 (Scammell), Project 3 (De Luca), and Project 4 (Vanderhost and Dymecki) will use this Core facility. These projects are not equipped to conduct in vitro electrophysiology recordings, and there are no institutional resources that can provide this service. These projects will benefit from the expertise and shared resources provided by the Core.

LOADING MOONBASE SCORE

NATIONAL HEART, LUNG, AND BLOOD INSTITUTEP01Heart, Lung, and Blood Program Project Study Section[HLBP (OA)]electrophysiologyrecordingsslicesvitropatch clampresources providedbrain slicesprovide services

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