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NOBEL PRIZE 2026

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NIHNATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASESR01

Immunologic and Clinical Sequelae after COVID-19 in Patients with Systemic Autoimmune Rheumatic Diseases

Active
Institution
BRIGHAM AND WOMEN'S HOSPITAL, MA
Principal investigator
Jeffrey Andrew Sparks
Funding
$706K
Duration
2023–2028
Open portfolio

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Abstract

PROJECT SUMMARY The 5 million Americans living with systemic autoimmune rheumatic diseases (SARDs), such as rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE), are at increased risk of poor COVID-19 outcomes. SARO treatment with immunomodulators may lead to blunted and dysregulated immune responses to vaccination and infection. SARDs are characterized by a predisposition to autoantibody formation and fibrosis. These factors may place SARDs at risk for poor short-term outcomes (e.g., breakthrough infection, prolonged viral shedding) and post-acute sequelae of COVID-19 (PASC), characterized by prolonged COVID-19 symptoms (>/=28 days). PASC is of high clinical and

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R01Neurological, Aging and Musculoskeletal Epidemiology Study Section[NAME]NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASESautoimmunesequelaeprolongedpascrheumaticrisk poorrheumatic diseasescovid-

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