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NOBEL PRIZE 2026

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NIHNATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

Molecular Immunology Core

Active
Institution
Massachusetts General Hospital, MA
Principal investigator
Leslie S Kean
Funding
$660K
Duration
2023–2028
Open portfolio

Moonbase score

Still being scored

Abstract

CORE SUMMARY / ABSTRACT The MIC will provide a centralized hub for advanced cellular and systems immunological analysis of all biologic samples derived from Projects 1-2. In addition, the MIC will coordinate and streamline all common assays and procedures to ensure that both Projects utilize uniform Standard Operating Procedures (SOPs) and best practices. The MIC is comprised of five interacting sub-Cores: (1) The MHC Immunogenetics and Typing Core; (2) the Flow Cytometry and CyTOF Core; (3) The Virology and Functional Protective Immunity Core; (4) The Molecular Immunology and Transcriptomics Core; and (5) The Computational Analysis Core. Each Core addresses an essential requirement for the optimal conduct of the complex experiments that are proposed in Projects 1-2 and promotes collaboration between investigators. As such, the MIC will significantly increase the efficiency and the rigor with which our group is able to execute the lung transplant tolerance experiments proposed in this U19.

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NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASESU19ZAI1-AM-Iproceduresimmunologytypingcollaboration investigatorscellular systemsexperiments proposedmiclung transplant

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