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NOBEL PRIZE 2026

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NIHNATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

Overcoming obstacles in structural elucidation of B cell antigen receptor assembly and lateral interaction

Active
Institution
BOSTON CHILDREN'S HOSPITAL, MA
Principal investigator
Hao Wu
Funding
$490K
Duration
2025–2027
Open portfolio

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Abstract

Abstract Development of effective adaptive immunity following infection and vaccination requires recognition of antigens and secretion of antibodies by B cells. T and B cells are the two major types of lymphocytes in the immune system. T cells can sense MHC-bound antigens by the T cell receptors (TCRs) and B cells can recognize free, unprocessed antigens by the B cell receptors (BCRs). Despite the critical importance of BCRs, how BCRs are assembled and regulated remain unclear. In this application, we propose to overcome certain technical obstacles in our pursuit of BCR assembly and regulation by engineering appropriate cell lines and using the native membrane environment for complex formation.

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NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASESR21Cellular and Molecular Immunology - A Study Section[CMIA]assemblyantigenscell receptorscells majordespite criticalinfection vaccinationobstaclesbcr

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