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NOBEL PRIZE 2026

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NIHNATIONAL HEART, LUNG, AND BLOOD INSTITUTE

Administrative Core

Active
Institution
INDIANA UNIVERSITY INDIANAPOLIS, IN
Principal investigator
Anthony B. Firulli
Funding
$360K
Duration
2017–2028
Open portfolio

Moonbase score

Still being scored

Abstract

Abstract Congenital heart disease (CHD) is the most common birth defect. Among various CHDs, defects that result in altered ventricular morphogenesis have the poorest clinical prognoses. Currently, there is a poor understanding of the molecular mechanisms and cellular etiology causative of the many forms of ventricular CHDs. The central theme of this Program Project Grant is to elucidate mechanisms that regulate growth and morphogenesis of the ventricle during development. Core A provides central administration of the Program Project Grant activities, which serves to enhance scientific interactions, resource sharing, collaborative interactions, and compliance requirements for all participants of this Program Project grant. The ultimate goal of Core A is to enhance Project efficiency and scientific output. Relevance: CHDs resulting in ventricle phenotypes have the poorest clinical outcomes. Thus, gaining an understanding of the etiology and molecular mechanisms that cause CHDs resulting in altered ventricular morphogenesis has the potential to benefit thousands of pediatric patients annually.

LOADING MOONBASE SCORE

NATIONAL HEART, LUNG, AND BLOOD INSTITUTEP01Heart, Lung, and Blood Program Project Study Section[HLBP]ventricularventriclemorphogenesisetiologyproject grantmechanisms cellularchdsprogram project

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