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NOBEL PRIZE 2026

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NIHNATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

Effect of aging and senescent cells

Active
Institution
UNIVERSITY OF MINNESOTA, MN
Principal investigator
David Masopust
Funding
$541K
Duration
2024–2029
Open portfolio

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Abstract

Project Summary The goal of this proposal is to understand how aging and senescent cells impact resident memory T cell differentiation, longevity, and functional interactions with individual tissue cell types, including parenchymal, stromal, innate and adaptive immune cells. Single cell assays will address gaps in understanding of resident memory T cell dialogue with resident hematopoietic and non-hematopoietic cells in both mouse and humans. The impact of the age of the organism, the age of the T cell, or targeted elimination of senescent cell populations will be tested as isolated variables. This study will inform mechanisms of immune disfunction in the elderly and therapeutic opportunities for rejuvenating tissue immunity.

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NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASESP01ZAI1-LP-Iresidentsenescent cellsresident memorysenescent cellfunctional interactionssenescenttissue cellmemory cell

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