Unraveling how neuropathic pain synaptic transcriptome is signaled by G-quadruplex folds

PROJECT SUMMARY Neuropathic pain is a pervasive and debilitating condition associated with modifications in synaptic plasticity and altered gene expression within the spinal cord. However, the specific molecular mechanisms underlying these synaptic changes remain poorly understood. This proposed project aims to unravel the synaptic transcriptome modifications occurring during neuropathic pain and investigate the involvement of G- quadruplexes in translocation of transcripts at the synapse. The outcomes of this study will provide a comprehensive map of the synaptic transcriptomic changes in neuropathic pain and elucidate some of the factors contributing to this alteration. Furthermore, it will pave the way for the development of innovative therapeutic strategies targeting the G-quadruplexes, ultimately offering new avenues for the management of neuropathic pain.