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NOBEL PRIZE 2026

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NIHNATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

Use of allogeneic pMHCII-based 5MCAR-CTLs to eliminate alloreactive lymphocytes in transplant

Completed
Institution
UNIVERSITY OF CALIFORNIA, SAN DIEGO, CA
Principal investigator
Gerald Patrick Morris
Funding
$228K
Duration
2024–2026
Open portfolio

Moonbase score

Still being scored

Abstract

PROJECT SUMMARY The immune system is a significant barrier to successful clinical organ transplantation, requiring life-long immunosuppression to prevent allograft rejection. Current immunosuppressive strategies rely primarily on broad pharmacologic inhibition of lymphocyte function. This approach is limited by susceptibility to breakthrough immune responses causing acute rejection episodes, with simultaneous unwanted impairment of protective immune responses against infection and tumors. Thus, new approaches for specific and durable allograft- specific immunosuppression are critically needed. We propose to utilize a pMHCII-based allogeneic 5-module chimeric antigen receptor-cytotoxic T cell (5MCAR-CTL) system to target and eliminate alloreactive CD4+ T cells. These investigations represent a conceptual advance in proposing to utilize cutting-edge cellular engineering with 5MCAR technology to develop a novel approach aimed at specific and durable immunosuppression in transplantation. Successful completion of the proposed experiments will generate tools and data to support refinement and development of this clinically-translatable cell engineering approach.

Research team

  • Michael S KuhnsPI
  • Gerald Patrick MorrisPI

LOADING MOONBASE SCORE

NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASESR21Special Emphasis Panel[ZRG1-IIDB-L(02)M]allogeneiceliminatetransplantationimmunosuppressiondurablerejectionalloreactiveallograft

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