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NIHNATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

Toxicity of saxitoxin congener mixtures in shellfish from Southeast Alaska

Active
Institution
Sitka Tribe of Alaska, AK
Principal investigator
Thomas F Webster
Funding
$82K
Duration
2024–2029

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Still being scored

Abstract

PROJECT SUMMARY / ABSTRACT Project 2 of the Knowledge Warding Against Toxin Levels Center will be co-led by Kari Lanphier, head of the Southeast Alaska Tribal Ocean Research Consortium, and Dr. Thomas Webster, an environmental health academic expert on chemical mixtures. The purpose of Project 2 is to evaluate different estimates of the toxicity of the saxitoxin congeners in shellfish. Specifically, Project 2 will (1) Compare predictions of shellfish saxitoxin-related toxicity using a bioassay (RBA) measuring total toxicity with estimates based on measurement of individual saxitoxin congeners (via HPLC) plus Toxic Equivalency Factors (TEF) from FAO/WHO; (2) test whether saxitoxin congeners adequately predict RBA using the TEF model; and (3) improve TEF estimates by regressing RBA against saxitoxin congener concentrations using new mixtures methods.

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NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCESP01ZES1-LKB-Kalaskashellfishtoxicitysoutheastmixturespurpose projectfaoestimates

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