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NOBEL PRIZE 2026

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NIHNATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCESR35

RNAse functions in post-transcriptional gene regulation

Completed
Institution
UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON, TX
Principal investigator
Ambro Van Hoof
Funding
$500K
Duration
2021–2026
Open portfolio

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Abstract

PROJECT SUMMARY All life forms must maintain a homeostatic gene expression program, which is achieved at many different steps in gene expression, including by the degradation of specific mRNAs and non-coding RNAs. Many evolutionarily conserved RNA processing enzymes mediate these key post-transcriptional events, with important roles for endo and exoribonucleases. A number of inherited diseases are caused by mutations in endo- or exoribonuclease genes, further underscoring their importance for human health. Eukaryotes use exonucleases for the degradation of most cellular mRNAs and for the 5' and 3' end processing of many different ncRNAs. In addition, endonucleases target specific mRNAs as an initiating step in mRNA degradation and other endonucleases process ncRNAs. This proposal will focus on the functional characterization of ribonucleases, especially functions in cytoplasmic mRNA degradation.

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R35NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCESSpecial Emphasis Panel[ZRG1-CB-K(55)R]rnasedegradationncrnasmrnasmrnadiseases causedregulation projectpost-transcriptional

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