Early-Phase Psychosis: Practice-Based Research to Improve Treatment Outcomes-Administrative Core

Project Summary/Abstract The overall goal of the ESPRITO Administrative Core is to support and improve CSC care and outcomes for LHS participants. The Core activities build on the success of the current ESPRITO in LHS enrollment (963) and CAB completion (2,600). It will provide the home for a range of critical CSC and LHS functions. It will be the base for leadership and linkage to the ENDCC and NIMH EPINET. The Program Project PI, Delbert Robinson will serve as PI of the Core and will serve on the EPINET Research Consortium. An Executive Committee will develop policy and review ongoing progress quarterly. A Core Operations Team led by Dr. Robinson will include the leadership of Research Projects and other Key Personnel. It will meet biweekly. This will allow the group to provide close coordination with the Operations Group led by Patricia Marcy that is responsible for direct interaction with our 13 sites and all reporting to the ENDCC that includes CABs, raw data and data analyses from our Research Projects. The Operations Group will also work to link site clinicians to dashboards developed by Clinical Informatics that are tailored to support measurement-based care with NAVIGATE, the CSC that all ESPRITO sites provide. This structure is designed to address EPINET requirements and profits from the extensive experience of the ESPRITO team in research with First Episode Psychosis (FEP), research and delivery of services in community clinical settings that provide CSC and almost five years of work in the current EPINET initiative. Our Prospective Practice-Oriented Research Project: Predicting hospitalization and disengagement with automated speech and language analysis and our Clinical Practice Research Project: Enhancing Patient Engagement in LHS Participation and in CSC Treatment are linked by providing complementary approaches to addressing disengagement. They also depend on the Administrative Core. For our automated speech and language analysis, the Operations Group will manage participant recruitment and retention as well as data collection. The Clinical Practice Research Project to enhance patient engagement takes advantage of CAB data and iterative interaction with sites and NAVIGATE clinicians that requires active engagement with the Operations Group. The Administrative Core also includes a statistics group that will apply innovative approaches to analyses of CAB data that are designed for communication to clinicians to support improved outcomes. ESPRITO sites span the US and are also diverse in terms of social determinants of health. We will employ multiple statistical approaches to understanding this diversity. Finally, Administrative Core leadership will use multiple methods including a learning collaborative to develop and nurture the next generation of leaders in providing CSC services and the future research that will be needed to ensure that the LHS model can continue to evolve and improve.