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NOBEL PRIZE 2026

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NIHNATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

Origin and function of atypical lymphocyte populations in inflamed tissue in SLE and RA

Completed
Institution
BRIGHAM AND WOMEN'S HOSPITAL, MA
Principal investigator
Betty Diamond
Funding
$721K
Duration
2021–2026
Open portfolio

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Abstract

A high-resolution analysis of cells in inflamed tissue offers the possibility of uncovering previously unappreciated pathogenic mechanisms and of identifying new therapeutic targets. In this project, we will characterize age/autoimmunity associated B cells (ABCs) in kidney and synovium of patients with systemic lupus and rheumatoid arthritis, respectively. We will explore their heterogeneity, derivation, localization, and antigenic targets as well as their functional interactions with T cell subsets, most specifically T follicular and T peripheral helper cells (Tfh/Tph). These efforts will provide a broad assessment of the features and potential functions of this highly expanded B cell population in human autoimmunity.

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NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASESP01ZAI1-TC-Iunappreciatedinflamedautoimmunityhelper cellssynoviumderivationfunctional interactionstfh

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