Caspr/11-dependent immunothrombosis and neuroinflammation during SARS-CoV-2 infection

PROJECT 2 - SUMMARY COVID-19 is caused by pulmonary infection with SARS-CoV-2 virus and has become a world- wide health problem. More than 6 million people passed away and among the survivors, 33% complain from symptoms that do not disappear after the acute phase of infection which is called Long-COVID. Notably, during infection, patients with COVID-19 suffer from thrombi in the lung and the brain which were implicated in the symptoms of long COVID. Our project will improve our understanding for the contribution of our innate immune system to thrombus formation and cytokine storm during SARS-CoV-2 infection in the brain and the blood circulation. We will also test suitable inhibitors in collaboration with other projects in this Program. Together, this project will provide novel information on immunothrombosis and brain pathology during COVID-19 that will allow the design of new therapeutic targets.