ANNOUNCEMENT

NOBEL PRIZE 2026

This year's laureates, their fields, and the discoveries that earned them the prize.Live nowSee the winners
Moonbase
← Back to Awards
NIHNATIONAL CENTER FOR COMPLEMENTARY & INTEGRATIVE HEALTHR01

Noninvasive sensory stimulation to promote glymphatic-lymphatic clearance for the treatment of Alzheimer’s Disease

Completed
Institution
Massachusetts Institute of Technology, MA
Principal investigator
Li-Huei Tsai
Funding
$542K
Duration
2021–2026
Open portfolio

Moonbase score

Still being scored

Abstract

Alzheimer's disease (AD) is an incurable brain disease, distinguished by the progressive accumulation of toxic amyloid and tau protein aggregates that are partly due to impaired waste clearance by the glymphatic and meningeal lymphatic systems. We have recently shown that noninvasive Gamma ENtrainment Using Sensory stimuli (GENUS) to induce neural oscillations in the gamma frequency range (30-90 Hz) could ameliorate pathology in various AD mouse models. Mice subjected to GENUS regime exhibited positive effects on microglia, astrocytes and the brain vasculature as well as reduced accumulation of amyloid and hyperphosphorylated tau in respective amyloid and tauopathy mouse models. However, the impact of GENUS on the glymphatic/lymphatic systems in the clearance of amyloid and tau accumulation is not clear. We will use amyloid and tauopathy mouse models to determine whether and identify the mechanisms by which GENUS enhances paravascular fluid movement and thereby promotes meningeal lymphatic drainage and glymphatic clearance of brain toxic metabolites including those associated with amyloid and tau.

LOADING MOONBASE SCORE

R01NATIONAL CENTER FOR COMPLEMENTARY & INTEGRATIVE HEALTHSpecial Emphasis Panel[ZRG1-BDCN-E(55)R]genusglymphaticmeningealamyloidlymphatictauclearanceamyloid tau

Questions for Massachusetts Institute of Technology

Answered by the team behind this research.

No questions yet. Sign in to ask the first one

Related grants

Same researchers, same institution, same topic, scored first.