2025 Cell Biology of Megakaryocytes and Platelets Gordon Research Conference and Gordon Research Seminar

PROJECT SUMMARY The Gordon Research Conference (GRC) and Gordon Research Seminar (GRS) on the Cell Biology of Megakaryocytes and Platelets is the premier international meeting in the field. Every other year, this conference brings together established and junior investigators, graduate and postdoctoral trainees, as well as interested industry scientists to communicate and discuss unpublished data that are critical to the development and disorders of the megakaryocyte lineage. The 2025 conference, the 10th of this GRC/GRS series, will provide a collegial and open setting to facilitate networking, promote discussion and foster collaborations among current and emerging leaders of the field. The long-term scientific mission of the conference is to bridge the gap between researchers working on various aspects of the lineage, including hematopoietic stem cells, megakaryocytes, and platelets. This mission is more relevant than ever, as the interdependence between each cell type becomes increasingly clear, such as the role of megakaryocytes in stem cell development, and the impact of inflammation on megakaryocyte growth and platelet production. More specifically, the 2025 conference aims to: 1. Highlight the extraordinary progress being made in our understanding of platelet function in the context of hemostasis, thrombosis, and inherited platelet disorders. 2. Discuss the latest unpublished research on the engineering of in vitro generated platelets. 3. Link the megakaryocyte/platelet lineage to immunity and inflammation. 4. Redefine the lineage and the bone marrow niche. 5. Examine state-of-the-art studies that push the field into new directions, including molecular mechanisms regulating platelet production and vascular interactions. To encourage interaction between researchers, we have combined megakaryocyte and platelet presentations in the same sessions. In addition, 10 high ranking abstracts will be selected for short oral presentations throughout the conference.