Genome Technology Center

PROJECT SUMMARY/ABSTRACT The Genome Technology Center (GTC) is a state-of-the-art, heavily utilized shared resource that provides expert, affordable, cost-effective, rapid turnaround genomic services to all Perlmutter Cancer Center (PCC) investigators and their collaborators across all New York University (NYU) campuses. GTC is essential to the research of the 4 Research Programs, as genomic analyses are central to most modern cancer research. During the funding period, 111 funded grants and 144 publications used GTC data, many co-authored by the director and key scientific staff. GTC is directed by Dr. Adriana Heguy, PhD, Professor of Pathology and Associate Dean for the Shared Resources at the Office for Science and Research at NYU Langone Health. She has more than 25 years of experience in genomics, 15 years of experience running core facilities at two institutions, and an international reputation in the field. She is assisted by 9 highly trained, expert scientists at the Masters’ and PhD levels. GTC resides in newly renovated, expanded space with a separate sequencing room, an automation suite, office space, and a small conference room that can be used by all PCC Shared Resources. Services offered include automated library preparation, short- and long-read sample preparation for a variety of applications such as whole genome and exome sequencing, bisulfite sequencing, RNA-Seq, single cell multi- omics sequencing, spatial transcriptomics, and multiple epigenomic and chromatin conformation approaches. GTC also educates PCC faculty, staff, fellows, and students who are interested in learning how genomic technologies can advance their research careers. GTC continuously grows and updates its instrument fleet to fit the needs of all PCC members and assesses client satisfaction via surveys and an internal advisory board. The Specific Aims of GTC are: 1) To provide a wide range of expert genomic services, including automated library preparation, sequencing, and to evaluate and implement emerging genomic technologies in order to continue providing state-of-the-art support for PCC members, 2) To facilitate genomic data sharing and storage through high performance computing (HPC) secure servers, including FASTQ file generation, analysis pipeline running and distribution of data to PCC investigators and bioinformaticians, and 3) To educate and inform members of the PCC community on genomic technologies and their use for cancer research through frequent informational and training seminars.