In Vivo Imaging Module

In Vivo Imaging (IVI) Module Summary The In Vivo Imaging (IVI) Module is a new module that replaces the previous Multiomics module. This module addresses increasing requests for instrument adaptations to tailor technology to specific research needs by our faculty and we anticipate extensive usage by multiple NEI-funded PIs. The IVI module will support research studies and projects relying on imaging animal and human subjects. The IVI module provides state-of-the-art instruments for imaging of the retina, lens, choroid, tumors, microcirculation, tear film and measurement of mechanical properties of the eye in patients and animal models of ocular disease. Specific Aims are: 1) To provide cutting edge in vivo imaging capabilities for clinical and basic science research in patients and animal models of ocular disease using instruments that are beyond reach of individual laboratories, 2) To provide dedicated personnel for training investigators and staff on advanced imaging techniques and operating specialized equipment and the associated analytic tools for in vivo image analyses, 3) To serve as a centralized resource for development of new instrumentation, adapting existing instruments for new uses and developing custom algorithms for image analysis. The main goal of the IVI module is that it will formally address users’ increasing imaging needs under the leadership of a module director and with a dedicated module manager, which will centralize imaging and analysis expertise to facilitate usage, maintenance and scheduling, training on and ensuring availability of the instrumentation. The IVI module will allow expanded application of imaging methods to additional researchers through collaborations, facilitate new collaborative projects with development of new instruments and specific adaptations of existing instruments with Department-subsidized customizing fees, allow more consistent scheduling of the instruments and training, provides technical expertise for grant proposals, and provides software for image processing and analysis. Custom-built modifications to imaging instruments will be charged a fee-for-service that includes components, raw materials, disposable supplies, equipment hire and a composite engineering fee. The fees will be reduced for NEI R01 holders to support novel research directions and collaborations by the Dept. Ophthalmology subsidizing 50% of the cost for IVI (see Chair’s letter). Equipment now consolidated in the IVI module has enhanced collaborations among NEI-funded investigators and was used to generate data that was reported in numerous publications and included in new grant awards. The IVI module will be an essential resource that supports highly innovative research at the forefront of translational research and allows collaborations among basic scientists and clinical faculty at BPEI, throughout UM and in other universities in the Miami area.