ANNOUNCEMENT

NOBEL PRIZE 2026

This year's laureates, their fields, and the discoveries that earned them the prize.Live nowSee the winners
Moonbase
← Back to Awards
NIHNATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKER01

Cortical Circuits Underlying Functional Recovery Following Stroke

Active
Institution
MEDICAL UNIVERSITY OF SOUTH CAROLINA, SC
Principal investigator
Takashi Sato
Funding
$378K
Duration
2023–2028
Open portfolio

Moonbase score

Still being scored

Abstract

Project Summary Stroke is one of the leading causes of long-term disability in the United States. Recovery from stroke-induced disability affects patients’ long-term quality of life. The goal of the proposed project is to unravel the circuit mechanisms underlying functional recovery after stroke. We will employ innovative approaches using state-of-the-art two-photon imaging techniques combined with optogenetic stimulation in mice. These approaches will allow us to monitor and manipulate the same neural circuits longitudinally. Through these novel approaches, we will test the hypothesis that different classes of neurons have different roles in stroke recovery. Our approach will provide the basis for identifying more effective interventions that promote stroke recovery through cell-type-specific manipulation.

LOADING MOONBASE SCORE

R01NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKEBrain Injury and Neurovascular Pathologies Study Section[BINP]strokefunctional recoverydisabilityoptogenetic stimulationdifferent classesrecovery followingcircuits underlyingrecovery

Questions for MEDICAL UNIVERSITY OF SOUTH CAROLINA

Answered by the team behind this research.

No questions yet. Sign in to ask the first one

Related grants

Same institution, same topic, scored first.