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NIHNATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCESR35

Administrative Supplement to: Decoding mechanotransduction mechanisms of cell-surface receptors

Active
Institution
UNIVERSITY OF MINNESOTA, MN
Principal investigator
Wendy Ryan Gordon
Funding
$89K
Duration
2016–2026
Open portfolio

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Abstract

PROJECT SUMMARY This supplement project is to support Erin Nolan in a PhD trainee and career development training experience alongside the goals of R35GM119483. Erin's mentoring and career development plan will enhance her organizational, writing, and presenting skills as well as provide ample opportunities to explore a variety of long- term career goals in biomedical research. Erin will engage with her mentors, Dr. Gordon and Dr. Largaespada, in weekly research and career development discussions. She will work on a research project to test the hypothesis that increased Ras signaling leads to increases in forces cells exert on their surroundings using a high-throughput assay based on DNA tension probes developed by the Gordon lab. She will also explore how cellular forces exerted by cells correlate with other cellular phenotypes to begin to address the broader question of how genetic changes in a cell contribute to cellular mechanical phenotype, and vice versa.

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R35NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCESMaximizing Investigators' Research Award C Study Section[MRAC]supplementcareer developmentexertedgenetic changescell-surfaceusing high-throughputgordonforces

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