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NOBEL PRIZE 2026

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NIHNATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

Gnotobiotics, Microbiology and Metagenomics Core

Active
Institution
BOSTON CHILDREN'S HOSPITAL, MA
Principal investigator
Wayne I Lencer
Funding
$277K
Duration
1997–2027
Open portfolio

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Abstract

Project Summary: The Gnotobiotics, Microbiology and Metagenomics Core (Core D), supports investigators studying functional roles of the microbiota in health and disease. Core D has supported >100 groups interested in evaluating mechanisms of action by which the host’s microbiota affects host physiologic and pathophysiologic processes. Our resources include a Microbiology Unit for microbiologic culturing, phenotyping, analysis of primary samples for microbial metabolite profiles, and develop defined consortia for functional studies, a Clinical Lab (CLIA) Unit to support microbiome-focused clinical trials, a Molecular Unit for sequence-based analyses, a Gnotobiotic (germfree) mouse facility for in vivo studies in animal models, a Metabolic Unit to support mouse metabolic cage, body composition and metabolism studies, and a Computational Unit which undertakes novel algorithmic development to evaluate longitudinal dynamics of the microbiota and assist users in experimental design for host-microbiota studies. Core D provides support to multiple academic centers in the greater Boston area.

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NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASESP30ZDK1-GRB-7culturingmicrobiologymicrobiotapathophysiologicmetagenomicscagegnotobioticunit

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