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NIHNATIONAL INSTITUTE ON AGINGR01

Locus Coeruleus Imaging Markers in Preclinical Alzheimers disease, Cerebrovascular Disease and Cognitive Decline

Active
Institution
UNIVERSITY OF SOUTHERN CALIFORNIA, CA
Principal investigator
Daniel A Nation
Funding
$1.6M
Duration
2023–2028
Open portfolio

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Abstract

Project Summary The proposed study will investigate brain imaging markers of a small brainstem nucleus called the locus coeruleus, which is important for cognitive function and is the first brain region to show Alzheimer’s disease- related changes in older adults who go on develop dementia. The study will examine brain imaging locus coeruleus markers in older adults who go on to have a healthy aging experience over time and in those who go on to develop Alzheimer’s disease, cerebrovascular disease and cognitive decline. By comparing the trajectory of changes in brain imaging markers of the locus coeruleus, we can better understand the potential value of these imaging markers for tracking disease progression from a very early stage.

Research team

  • Mark W BondiPI
  • Mara MatherPI
  • Daniel A NationPI

LOADING MOONBASE SCORE

R01NATIONAL INSTITUTE ON AGINGAcute Neural Injury and Epilepsy Study Section[ANIE]cerebrovascularbrain imagingcognitive declinelocus coeruleusmarkerscoeruleuscerebrovascular diseaselocus

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