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NOBEL PRIZE 2026

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NIHNATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

Development of Mechanisms Underlying Human Motor Learning

Active
Institution
HUGO W. MOSER RES INST KENNEDY KRIEGER, MD
Principal investigator
Amy J. Bastian
Funding
$687K
Duration
2021–2029
Open portfolio

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Still being scored

Abstract

Movement abilities affect a child’s physical, social and emotional well-being, as well as their educational success—all of which can last a lifetime. Movement is fundamental to the development of abilities across domains (motor, cognitive), because it underlies a child’s ability to explore and interact with the environment and other people. How children learn movement is a complex process that changes with development, experience and injury. It depends on a suite of interacting brain mechanisms that are driven by different signals (e.g. reward, error), have different learning rates, retention capacities, contextual dependencies and vulnerabilities to neurological damage. A key gap in human neuroscience is our limited understanding of this complex interplay. We propose to leverage recently developed home-based experimental tasks and new laboratory methods to generate high resolution time courses for different components of childhood motor learning, and then determine how they are affected by neurological lesions. With these data we can create a detailed flowchart of movement learning capacity and the effects of disease, as a function of age and developmental markers. This would provide the comprehensive understanding required to generate tailored therapeutic training strategies targeted to age, developmental maturity, gender, and disease state.

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NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKER35ZNS1-SRB-H(15)neurologicalabilitieschildmotor learningmotormotor cognitivephysical socialmovement

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