Administrative Core

Core A – Project Summary/Abstract Filoviruses are important emerging and biodefense pathogens with potential to impact global health. The overarching goal of this renewal Program Project Grant (PPG) application is to characterize host-viral interactions that contribute to filoviral infection, identify molecular interactions, and develop insights into molecular mechanisms. This interdisciplinary project will provide insight into host interactions that drive filoviral infections and identify new therapeutic targets. This multi-investigator collaborative effort will be conducted at several sites and the Administrative Core (Core A) will provide administrative oversight and coordinate interactions among sites to ensure that progress of this integrated research program will be maximized. Core A will: 1. Coordinate communication by virtual meetings and teleconferences among the PIs of the Research Projects and Scientific Cores, monthly web-based research-in-progress meetings, and an annual meeting among members of all participating groups. These meetings will facilitate reagent and scientific exchange among the different sites. 2. Coordinate annual meetings between the investigators and the External Advisory Board (EAB) to assess scientific progress and to facilitate the distribution of critical evaluations on the performance of the PPG. 3. Manage conflicts of interest and facilitate conflict resolution. 4. Coordinate fiscal administration and Scientific Core usage to ensure that the research projects are well supported. 5. Facilitate secure data sharing and access to inventory of reagents developed by Cores by implementing a cloud-based commercial database platform. 6. Assist investigators with preparation and submission of annual progress reports to the NIH and maintain a website for data dissemination. 7. Identify opportunities for training and professional development for trainees within the PPG group and facilitate their participation and promote cross training and expertise sharing. Through these collective actions, Core A will promote scientific interactions and provide support for seamless functioning of the overall scientific mission to discover and characterize key host- viral interactions that are critical for filoviral infections.