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NOBEL PRIZE 2026

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NIHNATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCESR35

Metabolic signals regulating cell growth versus survival

Active
Institution
UT SOUTHWESTERN MEDICAL CENTER, TX
Principal investigator
Benjamin P Tu
Funding
$380K
Duration
2020–2030
Open portfolio

Moonbase score

Still being scored

Abstract

Project Summary/Abstract: Over the previous funding periods, it was shown that acetyl-CoA and SAM are key signals of cellular metabolic and nutritional state. Acetyl-CoA is an activated carrier of two carbon units, while S-adenosylmethionine is the biological methyl donor in many reactions critical for life – these are two key metabolic currencies used by cells. This application proposes to continue investigating the mechanisms by which acetyl-CoA and SAM function to regulate important cellular pathways in balancing cell growth versus survival in response to metabolic and nutritional state. A combination of genetics, cell biology, and biochemistry will be utilized to elucidate how these sentinel metabolites are compartmentalized intracellularly and influence multiple aspects of the central dogma of molecular biology. Insights from these studies will be informative as to the role of these sentinel metabolites in aging and age-related diseases.

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R35NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCESMaximizing Investigators' Research Award C Study Section[MRAC]metabolitessentinelmetaboliccell growthacetyl-coacompartmentalizednutritionalsam

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