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NOBEL PRIZE 2026

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NIHNATIONAL INSTITUTE OF MENTAL HEALTH

Statistical methods to localize disease heritability and identify biological mechanisms

Active
Institution
BROAD INSTITUTE, INC., MA
Principal investigator
Benjamin Michael Neale
Funding
$824K
Duration
2015–2028
Open portfolio

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Abstract

Genetic studies of both common and rare genetic variation have been extremely successful in identifying genes and variants associated to schizophrenia, autism and other psychiatric disorders. Nevertheless, for most psychiatric disorders, the vast majority of genetic effects are as yet undetected. Our specific aims are to 1) quantify the heritability explained by rare and functional classes of variation; 2) boost association power via leveraging related traits; and 3) infer biological mechanisms via local fine-mapping and genome- wide causal inference. We will guide our research using >800,000 samples from genome-wide association, exome sequencing and genome sequencing studies of psychiatric disease. The methods we propose to develop will be implemented in software packages that we will make widely available to the community.

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NATIONAL INSTITUTE OF MENTAL HEALTHR37NSSpsychiatricpsychiatric disordersheritabilitycommon raregenes variantsbiological mechanismsavailable communityrare

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