Integrated Engineering and Rehabilitation Training

Enter the text here that is the new abstract information for your application. This section must be no longer than 30 lines of text. This proposal describes our “Integrated Neural Engineering and Rehabilitation Training” program that produces biomedical engineering Ph.D. graduates who combine state-of-the-art expertise in neural engineering (an area of bioengineering) with a genuine appreciation of the practice and challenges of clinical rehabilitation. This T32 is centered in the Department of Biomedical Engineering at Case Western Reserve University but also includes the strong participation of several of our local medical centers. Our T32 is focused exclusively on predoctoral training - having trained nearly 100 students since 1999, 66 in the last 15 years. We request funding for 9 predoctoral positions per year for five years and have an institutional commitment to supplement tuition, stipend, and training resources. We expect to train up to 27 BME Ph.D. students for two years each over the proposed 5 years. Trainees enter with undergraduate training in engineering or a closely related discipline. They satisfy the rigorous requirements of the BME Ph.D. program and benefit from its existing features, while our T32 program adds value through highly collaborative and interdisciplinary research projects, a clinical immersion experience, and unique access to visiting seminar speakers. Over the next 5 years, we will create and pilot AI-in Education activities and continue oversight with our established external Advisory Committee comprised of academic leaders in rehabilitation and neural engineering, representatives of large and small companies in the stimulation and rehabilitation commercial space, and practicing neural/rehabilitation physicians. The specific objectives of our training program are: (1) Prepare our trainees for productive careers in rehabilitation and neural engineering; (2) Provide a rigorous engineering education that forms the basis for future innovation; (3) Provide specific expertise in the development and application of neural stimulation and interventions for overcoming neurological disorders; (4) Provide specific expertise in modeling and simulation; (5) Provide an extensive, hands-on clinical immersion experience that prepares each trainee for a translational career; (6) Provide specific expertise in the deployment and integration of Brain-Computer Interfaces; and (7) Provide real-world professional development training to enhance post-graduation success. We have assembled a distinguished group of mentors who serve in one of three roles: Research Training mentors who are the primary research advisors of the trainees, Associate Research Training Mentors who are content experts on T32 trainee committees, and Clinical Training Mentors from rehabilitation and surgical disciplines who ensure the clinical relevance of each trainee research project. Trainee project topics include electrode development, stimulation pattern design, neural motor control mechanisms, neural biomaterials, immunomodulation of the neuroinflammatory response, deployment of interventions to individuals with neurological disorders, neurorehabilitation, modeling and simulation, and brain-computer interfacing.