A Research Community Hub and Data Resource for Integrated Neuropathological and Omics Analysis of Alzheimer's disease.

ABSTRACT (DATA CORE) The Seattle Alzheimer’s Disease Brain Cell Atlas (SEA-AD) project aims to create an AD/ADRD atlas and community data hub that builds on transformative brain atlasing efforts of the BRAIN Initiative Cell Atlas Network (BICAN) in the neurotypical brain to gain a deep understanding of AD pathology and disease progression. The Data Core team will build a valuable and catalytic community cell atlas describing the cellular and molecular changes occurring in Alzheimer’s Disease. It will organize and standardize the massive, multimodal datasets generated by SEA-AD2.0, using pipelines, data models, databases, and the security of the cloud-based Allen Institute Brain Knowledge Platform (BKP), to support access and communication across sites. The Dara Core will perform cross-project and cross-site integrative computational analysis, extending the primary analyses occurring within the SEA-AD2.0 Projects. This work will focus on creating models of disease progression through analysis of multi-site, multi-modality data from Projects 1-3, which will enable characterization of affected cell types in AD and AD/ADRD donors. To maximize community impact, the Data Core will also establish an Integrative Analysis Center (IAC) to foster joint analysis of single cell genomics datasets and associated representations of disease pathology across the AD/ADRD community through data harmonization and mapping all data to highly annotated BICAN/SEA-AD cell classifications. Finally, the Data Core will produce a public data hub and knowledge base to enable the research community’s access to the SEA-AD Consortium’s data on the molecular and cellular hallmarks of AD and AD/ADRD.