Core B

PROJECT SUMMARY The Exosome isolation and characterization Core (Core B) will provide the critical basis for the proposed projects by generating exosomes and carrying out their characterization together with content analysis for all scientific projects. The core will offer integrated services for exosome production and assessment of exosome contents from different cell supernatants and mouse and human plasma samples. Accordingly, Core B will maintain equipment and provide staffing to offer Projects the following services: 1) Exosome isolation and characterization, and 2) Assessment of exosome contents by molecular approaches and bioinformatics support. The Core is centrally located in the Center for Translational Medicine, medical education research building which also houses the cardiovascular research center and administrative offices. The Exosome core is composed of fully equipped exosome production and molecular analysis units. PPG investigators will be able to equitably utilize Core resources with the core designed specifically to serve this multi-project PPG. Accordingly, it will maximize quality control and enhance collaborations between projects, thus enhancing the synergy of this integrated research program.