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NIHNATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASESR01
Molecular basis of antibiotic resilience in Mycobacterium tuberculosis
Active
- Institution
- HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH, MA
- Principal investigator
- Sarah Fortune
- Funding
- $807K
- Duration
- 2024–2029
Moonbase score
Still being scored
Abstract
Summary We have identified a novel driver of treatment failure in Mycobacterium tuberculosis, termed antibiotic resilience, where the bacteria have improved recovery after antibiotic exposure. Population genomic and genetic studies implicate a novel transcriptional regulatory network in control of antibiotic resilience, which we will dissect through genomically informed structure-function studies and in treatment models.
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