Core C Protein Phenotype of Aging

CORE C: PROTEIN PHENOTYPES OF AGING – SUMMARY This Core is designed to support to the Aging Research Community by providing access to state-of-the-art proteomics technologies. The University of Washington Nathan Shock Center has been at the forefront of developing technologies to perform large-scale discovery-based and targeted proteomics assays that generate near complete data matrices, accurate quantitation, and high reproducibility – even across multiple laboratories. The primary goal of Core C is to apply these methods to studies of aging, to obtain accurate quantitative measurements of peptides from samples provided by its users, and to aid geroscience researchers in linking these high-dimensional data to biologically meaningful outcomes. In addition, the Core will develop and apply new assays especially suited to aging. This Core will work closely with Core D (Metabolic Phenotypes of Aging), Core E (Invertebrate Models of Aging), and Core F (Explainable Artificial Intelligence for Aging). We will collaborate with other NSCs and the broader aging research community as we have in the past. In doing this, we will assist in the discovery of proteomic changes that underlie the biology of aging and establish, disseminate, and aid in the implementation of new proteomics tools that allow us to advance studies of aging. Furthermore, we will collect proteomics data that can be used to create biological aging clocks and identify biomarkers that are associated with aging phenotypes.