Comparative Data Analytics Core

Project Summary (Comparative Data Analytics Core) Researching aging biology presents unique methodological challenges. To maximize the impact of aging research, it is essential to have a wide range of statistical expertise within and supporting research teams. The Comparative Data Analytics Core (Analytics Core) is dedicated to advancing aging research through statistical support and methodological innovation, offering unique expertise in rigor, reproducibility, and transparency. The Analytics Core serves a diverse portfolio of personnel, from NSC pilot award winners to other investigators in the field, by implementing rigorous design and analysis protocols and supporting investigators to meet high standards of rigor and transparency. Our team also engages in developing avant- garde methods to bring new techniques to the field. Our specific aims include providing statistical support to UAB and non-UAB investigators studying the comparative energetics of aging, utilizing traditional, specialized, and bespoke methods; conducting high-level statistical investigations of secondary data to answer questions about the comparative energetics of aging; developing and evaluating statistical methods needed in the field of comparative energetics of aging; and offering reproducibility, verification, and transparency support for aging researchers. In this renewal, to enhance research quality and culture, we also introduce a 'red team' approach, where our team critically evaluates research designs and analysis plans from volunteer research teams to identify potential methodological weaknesses before publication. This proactive strategy aims to prevent errors, thereby reducing the need for post-publication corrections and enhancing the field's reputation. In addition to these Core activities, we focus on training and fostering interdisciplinary exchange among researchers. Our efforts are aligned with the NIA’s objectives, particularly in fostering interdisciplinary research, enhancing collaboration, and developing the infrastructure necessary to translate research findings into practical interventions. By fostering rigorous, reproducible research, the Analytics Core will catalyze more informative research, advancing our understanding of aging biology. Our previous funding cycle demonstrated significant success, supporting investigators from 27 unique institutions and contributing to numerous completed projects and publications. We aim to build on this success by continuing to provide high-quality statistical support, developing innovative methods, and ensuring research rigor and transparency.