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NIHNATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

Functional Genomics Core

Active
Institution
University of Pennsylvania, PA
Principal investigator
Klaus H Kaestner
Funding
$114K
Duration
1997–2027
Open portfolio

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Abstract

SUMMARY The Functional Genomics Core (FGC) provides state-of-the-art experiment planning, sample preparation, quality assessment, library construction, DNA sequencing, and data analysis services to DRC members using state-of-the-art Illumina Sequencers including the high-throughput but flexible NovaSEQ 6000 system. We have experience with ChIP-seq, nucleosome mapping, whole exome and whole genome resequencing in mouse, human, zebrafish, and other species. We offer RNAseq, microRNAseq, GroSeq, CLIP-seq, nucleosome mapping, ATAC-Seq, ChIPseq, whole genome and targeted DNA methylome analysis, hydroxymethyl DIP, single cell ATACseq, single cell RNAseq and multiomics approaches. A goal of the FGC is to quickly adapt and occasionally develop new protocols for sequencing-based functional genomics analysis relevant to DRC members. We also offer a self-service sequencing services for advanced users at a minimal fee. Importantly, in response to DRC member requests, we provide extensive bioinformatics services, tailored to individual projects, to DRC members. The Core remains in high demand, with 46 current users. The FGC has provided data and analysis for over 70 research publications of DRC members during the past funding period and supported multiple grant applications. PHS 398/2590 (Rev. 09/20) Page FUNCTIONAL GENOMICS CORE: Director - K. Kaestner

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NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASESP30ZDK1-GRB-Srnaseqmembersnucleosomegenomicsfunctional genomicsdrcrevfee

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