ANNOUNCEMENT

NOBEL PRIZE 2026

This year's laureates, their fields, and the discoveries that earned them the prize.Live nowSee the winners
Moonbase
← Back to Awards
NIHNATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISMR21

Elucidation of the alcohol effect on tumor suppressor genes

Active
Institution
INDIANA UNIVERSITY INDIANAPOLIS, IN
Principal investigator
X. Charlie Dong
Funding
$228K
Duration
2025–2027
Open portfolio

Moonbase score

Still being scored

Abstract

Project Summary Chronic and excessive alcohol consumption is known to cause multiple diseases including alcohol- related liver disease and liver cancer. It is estimated that approximately 25% of cirrhosis deaths and ~20% of hepatocellular carcinoma (HCC)-related deaths in the world are associated with alcohol. However, the pathogenesis of the alcohol-related HCC remains incompletely understood. Tumor suppressor genes are known to have protective functions against cancer development. But very little is known which tumor suppressor genes are crucial in the alcohol-related HCC. In this application, we will use both candidate and systemic approaches to identify and characterize key tumor suppressor genes and their roles in the alcohol-related HCC development. It is expected that the findings from this innovative research will provide insights into risk assessment, HCC prevention, and therapeutic development.

LOADING MOONBASE SCORE

R21NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISMBiomedical Research Study Section[AA-1]genessuppressortumortumor suppressoralcoholliverhccalcohol-related

Questions for INDIANA UNIVERSITY INDIANAPOLIS

Answered by the team behind this research.

No questions yet. Sign in to ask the first one

Related grants

Same researchers, same institution, same topic, scored first.