ANNOUNCEMENT

NOBEL PRIZE 2026

This year's laureates, their fields, and the discoveries that earned them the prize.Live nowSee the winners
Moonbase
← Back to Awards
NIHNATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

Development of antimicrobials based on principles of induced proximity

Active
Institution
BROAD INSTITUTE, INC., MA
Principal investigator
Amit Choudhary
Funding
$481K
Duration
2025–2027
Open portfolio

Moonbase score

Still being scored

Abstract

PROJECT SUMMARY Small molecules have been classically developed to inhibit enzyme activity; however, new classes of small molecules that endow new functions to enzymes via proximity-mediated effect are emerging. Most of these chimeric molecules have been developed in the context of cancer. We propose to build chimeric molecules that recruit the immune system to bacteria. These molecules will be formed by joining together binders of proteins of the complement system and binders of bacteria and exhaustively characterized using biochemical, biophysical, and cell biology experiments. 1

LOADING MOONBASE SCORE

NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASESR21Chemical Biology and Probes Study Section[CBP]moleculesbindersbacteriasmall moleculesenzyme activitycharacterized usingchimericusing biochemical

Questions for BROAD INSTITUTE, INC.

Answered by the team behind this research.

No questions yet. Sign in to ask the first one

Related grants

Same researchers, same institution, same topic, scored first.