Advancing catheter electrochemical impedance spectroscopy for precision medicine of embolotherapy

Project Summary/Abstract: Catheter embolization is a critical treatment for multiple diseases, including hepatocellular carcinoma, uterine fibroids, renal cell carcinoma, and massive hemoptysis in cystic fibrosis. However, current embolization endpoint assessment is subjective, relying on intermittent X-ray imaging to evaluate blood flow qualitatively in the treated artery. Current X-ray embolization endpoint assessment methods are operator-dependent and not quantitative, leading to potential undertreatment or overtreatment. Our research aims to develop a novel method for quantitative flow assessment within the treated artery, providing a more accurate evaluation of embolization treatment. I propose integrating electrochemical impedance spectroscopy (EIS) sensors into catheters for real-time monitoring of embolization. Catheter sensing of embolization will reduce reliance on high-radiation techniques like quantitative digital subtraction angiography and avoid impracticalities associated with Doppler guidewires and intraoperative MRI flow assessment. In this project, I will miniaturize sensor catheter technology to microcatheters, that are commonly used for embolization and are able to track through small blood vessels. In addition, I will evaluate feasibility of new methods for continuous blood flow determination by the sensor catheters. Upon completion, this project will enhance the clinical translatability and utility of catheter embolization by realizing sensor microcatheters potentially providing continuous blood flow sensing. This innovation will have broad applications in intravascular flow sensing, benefiting fields such as interventional radiology and cardiology, ultimately improving the safety and efficacy of catheter procedures.