ANNOUNCEMENT

NOBEL PRIZE 2026

This year's laureates, their fields, and the discoveries that earned them the prize.Live nowSee the winners
Moonbase
← Back to Awards
NIHNATIONAL CANCER INSTITUTE

Gammaherpesviral interactions with the host cell

Active
Institution
UNIV OF NORTH CAROLINA CHAPEL HILL, NC
Principal investigator
Blossom A Damania
Funding
$347K
Duration
1997–2027
Open portfolio

Moonbase score

Still being scored

Abstract

Project 3 Project Summary Abstract Globally, oncogenic DNA viruses cause a significant cancer burden. These viruses establish life-long persistence in the human host and are associated with the development of epithelial, endothelial, and B cell cancers. The human gammaherpesviruses Epstein-Barr virus (EBV) and Kaposi's sarcoma-associated virus (KSHV) are associated with B cell lymphomas, Kaposi’s sarcoma, gastric cancer, and nasopharyngeal carcinoma (NPC). Moreover, human papillomavirus (HPV) is associated with oropharyngeal and cervical carcinoma. In this application, we propose to explore how the oncogenic gammaherpesviruses, KSHV and EBV, modulate cellular pathways including adenosine-related signaling pathways and how they contribute to oncogenesis. Investigating the various mechanisms involved in modulation of host immunity and oncogenesis by these tumor viruses will inform our understanding of the biology and pathogenesis of these viruses. Our findings will also pave the way for future therapies to treat virus-associated cancers.

LOADING MOONBASE SCORE

NATIONAL CANCER INSTITUTEP01ZCA1-RPRB-Lvirusesoncogeniconcogenesishostkaposicarcinomaebvkshv

Questions for UNIV OF NORTH CAROLINA CHAPEL HILL

Answered by the team behind this research.

No questions yet. Sign in to ask the first one

Related grants

Same researchers, same institution, same topic, scored first.