Interrogating Mechanisms of Anti-tumor Immunity in Human Subjects and Murine Models of IDH-Mutant Glioma Treated with All-Trans Retinoic Acid and PD-1 Inhibition

Project Abstract Diffuse gliomas are fatal brain tumors that respond poorly to current immunotherapies. Using both mice models and human clinical trial data, we propose a series of experiments to identify immune biomarkers and key immune cell types that predict tumor responsiveness to therapy. These results will further our understanding of brain tumor biology and inform the future development of new treatment modalities.