PDX Core

PROJECT SUMMARY / ABSTRACT U4HELPP PDX CORE A profound limitation to personalized approaches for therapeutic development in cancer is the lack of relevant patient derived models in all cancer types, especially those from underrepresented minority groups with more aggressive, recalcitrant and/or advanced clinical stages. The overall objectives of United for Health Equity in Living PDX Program (U4HELPP) will be to increase diverse representation and study of racial/ethnic minority populations through development and investigations on more racial/ethnically diverse patient-derived xenograft models (PDX) to advance cancer health disparity research. The U4HELPP PDX Core will serve as a central point for patient-derived viable tumor tissue harvest and expansion to fully support Research Projects 1 & 2 and Pilot Project and Trans-network Activities Core. The U4HELPP PDX Core will also serve as a central database of these specimens with clinical and molecular characteristics, including ancestry, of each cancer subtype, linked to molecular genomics.