ANNOUNCEMENT

NOBEL PRIZE 2026

This year's laureates, their fields, and the discoveries that earned them the prize.Live nowSee the winners
Moonbase
← Back to Awards
NIHNATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

Skin-Adipose axis in HLA-II mouse models of Group A Streptococcus infection

Completed
Institution
UNIVERSITY OF NORTH DAKOTA, ND
Principal investigator
Suba Nookala
Funding
$77K
Duration
2016–2026
Open portfolio

Moonbase score

Still being scored

Abstract

This proposal aims to establish proof of concept that i) downregulation of PPAR and impaired adipogenesis are a result of the dissemination of Group A Streptococcus (GAS) bacteria into the adipose niche during Necrotizing Soft Tissue Infections (NSTI), and ii) activation of PPAR by specific ligands might have a positive effect on reversing the impaired adipogenesis. Our studies aim to advance the understanding of the metabolic consequences and pathophysiological mechanisms underlying NSTI in varying genetic contexts for designing novel diagnostic and personalized therapeutic strategies to improve NSTI outcomes. The information gained from the proposed studies will present us with knowledge of hostdirected approaches as feasible adjuncts to antibiotic therapy and substantially transform the therapeutic strategies to promote favorable outcomes of NSTI and create healthy adipose tissue homeostasis.

Research team

  • Catherine Ayn BrissettePI
  • Suba NookalaPI

LOADING MOONBASE SCORE

NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCESP20ZGM1-RCB-3impairedstreptococcustherapeutic strategiesadipogenesisunderstanding metabolicinformation gainedadiposedesigning novel

Questions for UNIVERSITY OF NORTH DAKOTA

Answered by the team behind this research.

No questions yet. Sign in to ask the first one

Related grants

Same researchers, same institution, same topic, scored first.